Schizencephaly: a rare case with early diagnosis, management and review of literature

Schizencephaly or split brain is an uncommon congenital disorder of cerebral cortical development, belonging to the group cell migration defects. It characterized by presence a cleft in extending from surface piamater ventricles. A 21-year-old primigravida at 19+2 weeks gestation was referred our Outpatient department with level-2 ultrasound done 18+2 suggestive schizencephaly. First trimester genetic screening not done. Quadruple testing normal. After consultation and poor prognostication neonatologist, decision for medical termination pregnancy taken. Patient underwent mifepristone -misoprostol regimen. female abortus weighing 200 gm delivered. Gross examination showed only facial malformation form lip hypoplastic nose. Infantogram did reveal any skeletal deformity. On fetal autopsy, findings were consistent diagnosis schizencephaly (type 1). rare prenatal medicine grave prognosis. Majority cases are either diagnosed late present first decade life. Hence periodic surveillance during antenatal care help ultrasonography, such serious malformations can be managed early stage.